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Rapamycin seems to work by inhibiting a protein known as mTOR. Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis. Kobayashi et al. Cancer Sci., 2007;98:726 A multi-lineage screen reveals mTORC1 inhibition enhances human pluripotent stem cell mesendoderm and blood progenitor production. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. It also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity. 2016-06-11 · Rapamycin stops tumor growth in lab experiments, and similar drugs have been tested in people with a variety of cancers.

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The skin was just a very accessible human organ to study. Rapamycin has an anti-aging effect on the brain, heart, muscle, joints, bone, kidney, immune system, and eyes demonstrated in human or animal studies.

In lab experiments, the chemical has significantly lengthened the lifespan of yeasts, worms, fruit flies, and mice. It's currently being tested in pet dogs. If this trial is successful, rapamycin may then be tested in humans. Rapamycin seems to work by inhibiting a protein known as mTOR.
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Raw264.7 macrophages treated without or with Rapamycin (1 μΜ) or Chloroquine (20 μΜ) for 48 h.